History
Valproic Acid was first synthesized in 1882 by B.S. Burton as an analogue of Valeric Acid.
How it's Made
Valproic Acid is synthesized by the alkylation of ethyl cyanoacetate with two equivalents of propyl bromide, to give dypropylcyanoacetic ester. Hydrolysis and decarboxylation of the carbothoxy group gives 2-propylpentanenitrile, which is hydrolyzed into Valrpoic Acid.
Dosages
Delayed Release Tablets: 125 mg, 250 mg, 500 mg. Once a day
Extended Release Tablets: 250 mg, 500 mg. Twice daily
Sprinkle Capsules: 125 mg. Twice daily
Regular Capsules: 250 mg. Twice daily
Syrup: 250 mg/5 ml. Twice daily
Injection: 100 mg/5 ml. Twice daily
Try to take dosages at around the same time every day. It is recommended to take them with food, so as to not create an upset stomach.
Warning (NLM)
Before taking Valproic Acid, one should be aware of any allergies that they may have to medication.
One should tell their doctor about any other medication that they are taking.
It is important to notify one's doctor if you are breast feeding.
Do not take Valproic Acid with alcohol
If one's condition worsens while taking Valproic Acid, they should stop taking the medication and contact their doctor immediately.
Do not drive/operate machinery while taking Valproic Acid
Possible Side-Effects
-Drowsiness
-Dizziness
-Headache
-Diarrhea
-Constipation
-Changes in appetite
-Weight changes
-Back pain
-Agitation
-Mood Swings
-Abnormal thinking
-Uncontrollable shaking of a body part
-Loss of coordination
-Uncontrollable movement of eyes
-Blurred/double vision
-Ringing in the ears
-Hair loss
Some side-effects are more serious than others. If one experiences one of the following side-effects, they should contact their doctor immediately:
-Unusual bruising or bleeding
-Tiny purple or red spots on skin
-Fever
-Blisters or rash
-Hives
-Difficulty breathing/swallowing
-Confusion
-Tiredness
-Vomiting
-Drop in body temperature
-Weakness of joints
In case of an overdose, one should contact their local poison control center right away. If one has passed out from an overdose, a bystander should call 911 immediately.
Valproic Acid was first synthesized in 1882 by B.S. Burton as an analogue of Valeric Acid.
How it's Made
Valproic Acid is synthesized by the alkylation of ethyl cyanoacetate with two equivalents of propyl bromide, to give dypropylcyanoacetic ester. Hydrolysis and decarboxylation of the carbothoxy group gives 2-propylpentanenitrile, which is hydrolyzed into Valrpoic Acid.
Dosages
Delayed Release Tablets: 125 mg, 250 mg, 500 mg. Once a day
Extended Release Tablets: 250 mg, 500 mg. Twice daily
Sprinkle Capsules: 125 mg. Twice daily
Regular Capsules: 250 mg. Twice daily
Syrup: 250 mg/5 ml. Twice daily
Injection: 100 mg/5 ml. Twice daily
Try to take dosages at around the same time every day. It is recommended to take them with food, so as to not create an upset stomach.
Warning (NLM)
Before taking Valproic Acid, one should be aware of any allergies that they may have to medication.
One should tell their doctor about any other medication that they are taking.
It is important to notify one's doctor if you are breast feeding.
Do not take Valproic Acid with alcohol
If one's condition worsens while taking Valproic Acid, they should stop taking the medication and contact their doctor immediately.
Do not drive/operate machinery while taking Valproic Acid
Possible Side-Effects
-Drowsiness
-Dizziness
-Headache
-Diarrhea
-Constipation
-Changes in appetite
-Weight changes
-Back pain
-Agitation
-Mood Swings
-Abnormal thinking
-Uncontrollable shaking of a body part
-Loss of coordination
-Uncontrollable movement of eyes
-Blurred/double vision
-Ringing in the ears
-Hair loss
Some side-effects are more serious than others. If one experiences one of the following side-effects, they should contact their doctor immediately:
-Unusual bruising or bleeding
-Tiny purple or red spots on skin
-Fever
-Blisters or rash
-Hives
-Difficulty breathing/swallowing
-Confusion
-Tiredness
-Vomiting
-Drop in body temperature
-Weakness of joints
In case of an overdose, one should contact their local poison control center right away. If one has passed out from an overdose, a bystander should call 911 immediately.